ABSTRACT
Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which organs, tissues, and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. SLE primarily occurs in young women in their twenties. The disease expression is greatly influenced by the combined effect of genetic, environmental, demographic and geographical factors. Genetic factor superimposed on certain environmental factors plays a very pivotal role in manifesting abnormal immunological response. There is a wide variation in the natural history of systemic lupus erythematosus among different ethnic and geographical groups. Severity ranges from a mild disease with rash and arthritis to a devastating illness with renal failure and central nervous system involvement. The purpose of this study is to delineate the clinical pattern and disease course in patients with SLE at our centre and to compare it with National data on lupus patients. Aim and objectives: To describe the clinical profile in systemic lupus erythematosus patients and to assess the disease activity of SLE with SLEDAI criteria in SLE patients. Materials and methods: This study was an observational study conducted in 50 patients of Systemic Lupus Erythematosus who were admitted in Department Of Medicine, Gandhi Hospital, Telangana during the period from January 2017 – June 2018. Aishwarya Sirikonda, Mrudula Kolli, M. Raja Rao, Shyamala Srujana. A study of clinical profile and assessment of disease activity in systemic lupus erythematosus patients. IAIM, 2019; 6(10): 22-27. Page 23 Results: The age of the patients ranged from 16 to 48 years with a mean of 26.52 years. Diagnosis was based on the SLICC criteria for the diagnosis of SLE. All the patients satisfied at least 4 criteria needed for diagnosis of SLE as per the recommendations. Conclusion: